1. Cognitive health.
   

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2. Heart health.
   

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3. Cancer protection.
   

Still, more research is needed.

Mitochondria are the powerhouses that make energy inside every cell in our bodies. As we age, mitochondrial function becomes slowly impaired. Resveratrol has been shown to penetrate cells and help rejuvenate the mitochondria thus supporting healthier living.

Resveratrol (a.k.a. trans-resveratrol) is a natural phytoalexin compound, found in red grape skin, Japanese knotweed, peanuts, blueberries, and some other berries. In nature it is produced by some plants in response to stress, injury, infection or ultraviolet (UV)-irradiation. In humans, resveratrol has raised attention not only for being a very effective antioxidant but also exhibiting a number of complementary functions on cellular and systemic levels, leading to a plethora of beneficial health effects. Since then, scientific interest for this polyphenol has increased exponentially. Today, resveratrol is recognized for its beneficial effects on, amongst others, cardiovascular health, blood glucose support, bone health, memory and skin health. Resveratrol is therefore widely used as a key ingredient to support healthy living.

One of the most pterostilbene-rich sources is the blueberry. At most, there is about 0.18mg of pterostilbene per 300 grams of blueberries.

Pterostilbene is a powerful antioxidant that many researchers believe to be a significant tool in the fight against aging and age-related illness. Notably, pterostilbene is a polyphenol. This unique class of plant-based compounds is widely researched for its potential to promote healthy aging by preventing cellular damage and disease. Other well-known foods rich in Pterostilbene include blueberries, cranberries, and dragon fruit.

Pterostilbene is perhaps most similar to resveratrol, the plant-based antioxidant from grapes that gives red wine its purported health benefits. However, there are significant differences when comparing pterostilbene to resveratrol and other polyphenols, including:

1. Evidence suggests pterostilbene is up to 4x more bioavailable than resveratrol.
   

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2. So far, research suggests pterostilbene may provide greater health benefits than resveratrol.
   

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3. Fewer studies have been conducted on pterostilbene, however, and more formal studies are needed.
   

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Lecithin contains phospholipids like phosphatidylcholine. Phospholipids are a type of fat combined with phosphate. Your body converts phosphatidylcholine into choline. Choline supports cell structure in the following areas of your body:

1. Brain.
   

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2. Nerves.
   

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3. Cell membranes.
   

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Use of piperine as a bioavailability enhancer

Process for making high purity piperine for nutritional use

Related certifications

Lycopene’s main health benefit is its antioxidant function.

Antioxidants are molecules that fight free radicals in our bodies. Free radicals build up naturally in response to aging, but their levels increase due to environmental and behavioral factors like pollution and smoking.

Free radicals cause cell damage — in high levels, this damage is linked to a wide range of health conditions, including cancer, diabetes, and heart disease. By stabilizing these free radicals, scientists believe that lycopene may reduce the risk of developing chronic illnesses.

While research is ongoing, lycopene may also promote good oral health, bone health, and blood pressure.

In addition, lycopene is thought to have these other health benefits:

1. Reduced Cancer Risk
   While more research is needed, studies have found a connection between lycopene intake and cancer prevention — particularly for bone, lung, and prostate cancers. Experimental studies have shown that lycopene slows or stops the growth of cancer cells. It’s thought that this effect is due to lycopene’s uniquely strong antioxidant abilities. Because it's not changed into Vitamin A in our bodies like most carotenoids, scientists believe its antioxidant properties are enhanced, helping to reduce cell damage that can lead to cancer.

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2. Heart Health
   A recent study found evidence that lycopene reduced bad cholesterol (LDL) while increasing good cholesterol (HDL) levels. This balance is important because high cholesterol develops fatty deposits in our blood vessels, which can clot and lead to a heart attack or stroke. In addition, lycopene can help to maintain good blood pressure, further reducing the risk of heart disease.

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3. Skin Health
   Long-term lycopene consumption is also linked with skin cancer prevention. Several studies show that people who included tomato paste in their diet daily experienced up to 40% less ultraviolet (UV) skin damage from sunlight than those who did not. While tomatoes can’t substitute for sunscreen, researchers found lycopene to provide a consistent level of skin protection, similar to a sunblock with SPF 1.3 protection. In addition, lycopene was shown to boost levels of procollagen in the skin significantly, which scientists believe has the potential to reverse skin damage caused by aging.

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4. Improved Fertility in Men
   A recent study found that consuming 14 milligrams a day of lycopene can improve fertility in healthy young men by about 40 percent.

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5. Pain Relief
   Lycopene has been shown to reduce pain to a degree similar to that of ibuprofen medication. Several studies have looked at its effects on nerve pain — which is traditionally very difficult to treat. The results in animals are promising, showing significant levels of decreased pain and hypersensitivity from lycopene intake.

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6. Health Risk
   Lycopene is considered safe and there are no established upper limits recommended for its consumption. While research is ongoing, there are not currently any known negative side effects associated with taking lycopene. However, high levels of lycopene (more than 40mg daily) may not be suitable for:
   • People with low blood pressure
   • People with stomach ulcers
   • Pregnant or breastfeeding women
   • People using hormone therapy

Quercetin is used for a variety of potential health benefits, from heart and brain health to allergies. Quercetin can be:

1. Has Antioxidant Effects
   As a part of normal metabolism, the human body produces compounds called free radicals. Free radicals damage healthy cells, trigger gene mutations, accelerate aging, and increase the risk of various diseases, including heart disease and diabetes. Quercetin has been shown to counter the harmful effect of free radicals through its strong antioxidant activity. This antioxidant effect can help the body maintain a stable state, ward off premature aging, and reduce chronic disease risk. Much of this research has been done in cells or animals, but researchers suggest the effect is likely true for humans too.

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2. Has Antimicrobial Effects
   Several studies have found that quercetin offers broad-spectrum antibacterial properties. Quercetin has been shown to protect against Salmonella enteritidis (salmonella), Staphylococcus aureus (staph), and Escherichia coli (E. coli) in part by destroying bacterial cell walls and changing cell function. Quercetin has also been shown to interfere with the growth of drug-resistant microorganisms. This means quercetin may help fight against strains of bacteria that don’t respond to treatment. Quercetin is particularly effective against bacteria that affect the skin, as well as the digestive, respiratory, and urinary systems. It’s also been shown to combat some viruses and fungi.

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3. Protects Heart Health
   Quercetin guards heart health in several ways. It has been shown to reduce both systolic (the top number) and diastolic (the bottom number) blood pressure. Quercetin can also reduce the pressure on arteries.5 That’s important because, over time, high blood pressure can damage arteries and lead to heart disease. Quercetin has also been shown to curb total cholesterol and triglycerides. Triglycerides are a type of fat that, in high amounts, can increase your heart disease risk. Quercetin can also counter a process called oxidation, which changes “bad” low-density lipoprotein (LDL) cholesterol in ways that harden arteries. Quercetin can also help regenerate blood vessels to improve blood flow, which supports healthy heart function.

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4. May Help Weight Management
   Only a limited number of human studies have evaluated the effects of quercetin on obesity treatment, but the results are promising. In one small study, six men and 30 women who were overweight or had obesity were randomly assigned to take either 100 milligrams (mg) of quercetin or a placebo every day for 12 weeks. The researchers found that the quercetin group had significant decreases in weight; body mass index; and waist, hip, and thigh measurements. The quercetin group also had a reduction in overall body fat percentage, particularly in the arms. More research—especially in larger numbers—would be needed to say for certain the effect quercetin can have on weight loss or how quercetin would fit into an overall weight management plan.

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5. May Protect Brain Health
   Alzheimer’s disease is the most common cause of dementia among older adults. Over time, it destroys memory and thinking. Flavonoids, the family of antioxidants to which quercetin belongs, have been extensively studied for their antioxidant and anti-inflammatory activities—both of which are important in the prevention of Alzheimer's. Research has shown that flavonoids as a whole may be able to help prevent the development or progression of Alzheimer's. Research on how the flavonoid quercetin affects Alzheimer's has been primarily animal-based. But one study in humans looked at the impact of quercetin-rich onion powder on cognitive function in 70 healthy Japanese adults aged 60-79. The participants were randomly assigned to consume either 11 grams of air-dried, high-quercetin onion powder or a placebo daily for 24 weeks. The results showed quercetin-rich onion powder may delay cognitive decline in older adults with early stage Alzheimer's. The researchers also found the quercetin group experienced better cognitive function scores, improved depressive symptoms, and increased overall motivation.

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6. May Support Immune Function
   Studies regarding quercetin and immune function have had mixed results, but there is some promise that the flavonoid can support immune function. In one trial, 1,002 participants took 500 mg or 1,000 mg of quercetin or a placebo each day for 12 weeks. Overall, quercetin supplementation did not have a significant effect on rates of upper respiratory tract infections, such as colds, compared with the placebo. However, in a subgroup of participants aged 40 or older who rated themselves as physically fit, 1,000 mg of quercetin per day resulted in fewer total sick days and a reduced severity of upper respiratory tract infection symptoms. Another small study among athletes found that supplementing with 100 mg of quercetin per day did not impact several measures of immune function after three days of intense exercise, but it did significantly reduce upper respiratory tract infection risk. In the two-week period after the exercise sessions, just one out of 20 participants in the quercetin group got sick compared to nine of 20 in the placebo group.

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7. May Help Improve COVID-19 Outcomes
   There have been more than a dozen clinical trials to evaluate the effects of quercetin on the prevention and treatment of COVID‐19. One of those studies looked at the effect that a product made from quercetin and sunflower lecithin—which increases the rate of quercetin absorption by up to 20 times compared to pure quercetin—had on 152 people with COVID-19. Researchers found when the supplement was used in the early stage of COVID‐19 infection alongside conventional COVID‐19 therapies, patients had improvements in early symptoms and a reduced risk of severe COVID‐19 outcomes, including hospitalization. Still, more clinical trials are needed to firmly establish the effectiveness of quercetin supplements against COVID‐19. The National Institutes of Health (NIH) included quercetin in its review of supplements for COVID-19. In that review, the NIH said that there wasn’t enough information to make a determination for or against the use of any supplement when preventing or treating COVID-19.

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8. May Aid in Autoimmune Conditions
   Autoimmune diseases occur when the immune system mistakenly attacks your body’s healthy cells. Some of these conditions include rheumatoid arthritis (RA), inflammatory bowel disease, multiple sclerosis, and lupus. Due to its protective anti-inflammatory and antioxidant abilities, quercetin may help prevent or manage autoimmune conditions. For example, in one small study, 50 women with RA were randomly assigned to receive either 500 mg of quercetin or a placebo every day for eight weeks. The quercetin group experienced significant reductions in early morning stiffness, morning pain, and post-activity pain compared with the placebo group. In addition, the number of patients with active RA disease in the quercetin group significantly decreased.

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9. May Help Regulate Effects of PCOS
   Polycystic ovary syndrome (PCOS) is a common cause of infertility, affecting 6%-12% of U.S. women of reproductive age. People with PCOS have higher levels of the male hormone androgen than people with female reproductive systems usually have. The levels of androgen can lead to several symptoms, including a stop in ovulation. People with PCOS are also often insulin resistant, which means their bodies make insulin but can’t use the insulin effectively. This can increase the risk of type 2 diabetes. A limited number of human studies have looked at the impact of quercetin supplements vs. a placebo on PCOS for up to 12 weeks. So far, the research has shown positive outcomes, with quercetin users experiencing improvements in both hormone and insulin regulation. However, scientists say there are not enough studies to make strong conclusions about the use of quercetin supplements for PCOS.