GMIPLUS® Immuno Protein

GMIPLUS® is an immune-modulatory protein derived from Ganoderma microsporum. It is cultivated by S. cerevisiae through sophisticated biological genetic medicine process. It has multiple immune modulation and anti-cancers effects. Clinical evidences had shown it's immunologic balancing and enhance metabolism, in further it can inhibit multiple cancers stem cells.

GMIPLUS® Immuno Protein

8 Major product features

The National Institutes of Health (NIH) has confirmed through experiments that GMIPLUS® has an inhibitory effect and killing effect on a variety of cancer cell lines, and has obtained a medical certificate of "treatment of cancer cell invasion and migration". Medical research of publish shown that GMIPLUS® can be combined use with anticancer drugs -Cisplatin, to reduce the resistance of cancer stem cells.

GMIPLUS® Immuno Protein

mainefficacy and research patents

Obtained medicinal evidence for the treatment of cancer cell invasion and metastasis: NIH experi ments in the United States have found inhibitory and killing effects on a variety of cancer cell lines, including non-small cell lung cancer, lung and head and neck squamous cells. Cancer, breast cancer, brain cancer, bladder cancer, liver cancer, colorectal cancer, rectal cancer, colon cancer, melanocyte carcinoma, blood cancer, kidney cancer.

It can improve blood sugar regulation and liver triglyceride accumulation.

It also has partial anti-inflammatory effects.

Promotes neurite outgrowth, repair and regenerate the nervous system.

Sun Yat-sen University of Medical Research has confirmed that GMIPLUS not only can significantly inhibit cancer stem cell proliferation, invasion and metastasis, but also suppress the resistance of cancer stem cells with cisplatin. GMIPLUS is used to feed nude mice (immunized hypoxic mice) that have been previously inoculated with cancer stem cells, even Slows the rate of tumor growth.

Blocking the IL6/Stat3 message transmission pathway is one of the mechanisms by which GMIPLUS inhibits cancer stem cells.

Taiwan University, Yangming University, ITRI Health Center, a number of scientific research units validated!

The CRO (commissioned research institute) completed the acute toxicity and sub-chronic toxicity tests, and obtained international authoritative patents.

The first brewer's yeast immunoregulatory protein

FIP-GMIPLUS® verified by transnational research

Among the different members of this migratory Ganoderma lucidum immunoregulatory protein family, the FIP-GMI immunomodulatory protein purified from S. cerevisiae has been researched and developed by an international team for nearly two decades. The FIP-GMI immunomodulatory protein has been confirmed In unique clinical functions of immune regulation, tumor suppression and other anti-aging, blood sugar regulation and other body-building effects. It has been recognized and protected by many globally patents, and also obtained the US Food and Drug Administration (USFDA) New Dietary Ingredients (NDI) approved.

The mechanism of action of the yeast immunoregulatory protein FIP is currently a subject of active research in the biomedical community! Based on the results of Taiwan and cross international research institutes, we found that the yeast immunomodulatory protein FIP-GMI can regulate cells containing T cells, B cells, and dendritic cells in the human body. Through the role and balance of Cellular Immunity, which in turn achieves physiological balancing and repairment.

2013

The NIH experiment in the United States found that it has inhibitory effects on variety of cancer cell lines.

2016

Obtained FDA certification and passed the highest food safety standards.

In 2013, the National Institutes of Health (NIH) conducted experiments and found that it inhibited more than 60 cancer cell lines. So far, there have been more than 300 clinical trials and no deaths. In 2016, it was certified by the US FDA. The highest food safety standards allow users to feel more at ease and peace of mind.
GMIPLUS® is a small molecule protein that belongs to a single side and can achieve systemic regulation and autoimmune improvement to achieve a comprehensive improvement.
The FIP-GMI Saccharomyces cerevisiae regulatory protein has been approved by the US Food and Drug Administration (US FDA) New Dietary Ingredients (NDI) safety approval for many years of trans-Pacific multinational research.

US Food and Drug Administration NDI

Safety Certification.

GMIPLUS® Immuno Acquired multiple research patents

US Patent US7601808

US Patent US8476238

US Patent US9018171B2

US Patent US9161964B2

US Patent
US9827288B2

US Patent US20160115208A1

US Patent US20160184389A1

US Patent US20190091286A1

Taiwan Patent I299735

Taiwan Patent I414307

Taiwan Patent 201625286

China Patent CN107287166A

PCT International Patent WO2016062239AI

GMIPLUS® Immuno Protein THREE functions advantages

Hsin IL, Ou CC, Wu TC, Jan MS, Wu MF, Chiu LY, Lue KH, Ko JL. GMI, an immunomodulatory protein from Ganodermamicrosporum, induces autophagy in non-small cell lung cancer cells. Autophagy. 2011;7(8):873-82.

Hsin IL, Ou CC, Wu MF, Jan MS, Hsiao YM, Lin CH, Ko JL. GMI, an Immunomodulatory Protein from Ganodermamicrosporum, Potentiates Cisplatin-Induced Apoptosis via Autophagy in Lung Cancer Cells.Mol Pharm. 2015;12(5):1534-43.

Chiu, L.-Y., Hu, M.-E., Yang, T.-Y., Hsin, I.-L., Ko, J.-L., Tsai, K.-J., &Sheu, G.-T. Immunomodulatory Protein from Ganodermamicrosporum Induces Pro-Death Autophagy through Akt-mTOR-p70S6K Pathway Inhibition in Multidrug Resistant Lung Cancer Cells. PLoS One. 2015; 10(5): e0125774.

Lin, C.-H., Hsiao, Y.-M., Ou, C.-C., Lin, Y.-W., Chiu, Y.-L., Lue, K.-H., …Ko, J.-L. (2010). GMI, a GanodermaImmunomodulatory Protein, Down-regulates Tumor Necrosis Factor α-Induced Expression of Matrix Metalloproteinase 9 via NF-κB Pathway in Human Alveolar Epithelial A549 Cells. Journal of Agricultural and Food Chemistry, 58(22), 12014–12021.

Li, C.-H., Ko, J.-L., Ou, C.-C., Lin, W.-L., Yen, C.-C., Hsu, C.-T., & Hsiao, Y.-P. (2019). The Protective Role of GMI, an Immunomodulatory Protein FromGanodermamicrosporum, on 5-Fluorouracil-Induced Oral and Intestinal Mucositis. Integrative Cancer Therapies, 18, 153473541983379.

Sea Buckthorn Extract

Sea Buckthorn, scientific name Hippophae rhamnoides L., is a hardy deciduous shrub native to Asia and Europe. The fruit is orange. Sea buckthorn oil is rich in vitamins, minerals, flavonoids, Omega-3, Omega-6, Omega-9 fatty acids, and the extremely rare Omega-7 fatty acids, which have rich nutritional and medical value. Because they can survive in harsh environments, they have the reputation of "the miraculous fruit in the desert."

Five Functions Of Sea Buckthorn

Contains Various Of Nutrients

Sea buckthorn is rich in fat-soluble vitamins A, D, E, K, water-soluble vitamins B1, B2, B6, B12, C, folic acid, biotin, and minerals such as potassium, calcium, magnesium, iron, and phosphorus, each of which is 100% Keyo contains 695mg of vitamin C, which is 15 times that of oranges.

Sea buckthorn oil is also one of the only plant foods to provide four omega fatty acids (omega-3, omega-6, omega-7, and omega-9). Among them, the high concentration of omega-7 palmitoleic acid helps reduce the risk factors of heart disease, reduce platelet aggregation, avoid thrombosis, stabilize blood pressure, balance cholesterol, and maintain skin health.

Omega-7 Fatty Acid—Palmitoleic Acid

1. Support heart health

Omega-7 fatty acids can prevent thrombosis and regulate the immune system, thereby reducing inflammation and protecting heart health.

2. Reduce insulin resistance

Omega-7 fatty acids help increase insulin sensitivity and promote glucose metabolism.

3. Maintain skin health

Palmitoleic acid can increase the synthesis of elastin and collagen, making the skin youthful and moisturizing.

4. Reduce inflammation and relieve dry eye discomfort

By inhibiting inflammatory cytokines, reduce inflammation in the body,and even reduce the inflammation and pain of dry eye.

5. Balancing Cholesterol

Omega-7 fat helps increase HDL (high-density lipoprotein) cholesterol and lower LDL (low-density lipoprotein) cholesterol by balancing High-sensitivity C-reactive protein(hs-crp).

In addition, sea buckthorn is also rich in antioxidant nutrients, which help protect the body against aging, heart disease, cancer, and other diseases. For example, bioflavonoids include Quercetin, Isorhamnetin, and proanthocyanidins. (Proanthocyanidins), catechins (Catechin), etc., have an extremely high antioxidant capacity to strengthen blood vessel health. In addition, Phytosterols can increase the skin barrier, protect the skin from external damage, reduce water loss, and improve skin elasticity and help wound healing.

Sea Buckthorn Extract Five functions advantages

Olsson, M. E., Gustavsson, K.-E., Andersson, S., Nilsson, Å., & Duan, R.-D. (2004). Inhibition of Cancer Cell Proliferation in Vitro by Fruit and Berry Extracts and Correlations with Antioxidant Levels. Journal of Agricultural and Food Chemistry, 52(24), 7264–7271.

Johansson, A. (2000). Sea buckthorn berry oil inhibits platelet aggregation. The Journal of Nutritional Biochemistry, 11(10), 491–495.

Ganju, L., Padwad, Y., Singh, R., Karan, D., Chanda, S., Chopra, M. K., … Sawhney, R. C. (2005). Anti-inflammatory activity of Seabuckthorn (Hippophae rhamnoides) leaves. International Immunopharmacology, 5(12), 1675–1684.

Yang, Z.-H., Miyahara, H., & Hatanaka, A. (2011). Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes. Lipids in Health and Disease, 10(1), 120. doi:10.1186/1476-511x-10-120

Xing, J., Yang, B., Dong, Y., Wang, B., Wang, J., & Kallio, H. P. (2002). Effects of sea buckthorn (Hippophaë rhamnoides L.) seed and pulp oils on experimental models of gastric ulcer in rats. Fitoterapia, 73(7-8), 644–650.

Aronia Melanocarpa Extract

Aronia berry, scientific name Aronia melanocarpa, also known as Black chokeberry, is mainly grown in eastern North America and spread to Europe in the 18th century. They are usually used to make jam, wine, flavoring, or tea. The fruit contains high anthocyanin content. , Effectively reduce cell lipid peroxidation, thus reducing the risk of many diseases.

Wild cherry berry is the berry with the highest anthocyanidin content, the ORAC antioxidant index of the fruit is the champion, ORAC is as high as 16,062 umol TE/100g.

ORAC

Oxygen free radical absorption capacity

Oxygen radical absorbance capacity ORAC (Oxygen radical absorbance capacity) is an international unit for measuring the antioxidant capacity of different foods, namely umol TE/100g. It does achieve by combining a food sample with some molecules that generate free radical activity. Some Easily oxidized molecules are put together in a test tube to quantify the "total antioxidant capacity" of the food. The higher the value, the stronger the ability to scavenge free radicals and improve the antioxidant capacity.

Total-Oxygen free radical absorption capacity (µmol TE/100g)

The dark-colored wild cherry berries are rich in anthocyanins. Every 100 grams of fresh wild cherry berries contains up to 1480 mg of anthocyanins. Anthocyanins are bioflavonoids and have free radical scavenging and antioxidant capabilities., So it can reduce the risk of metabolic syndrome.

Total anthocyanins (mg/100g)

Aronia melanocarpa Extract Two functions advantages

Aronia berries provide antioxidants. These compounds may have cancer-fighting properties and support your heart and immune health.

Sharif, T., Alhosin, M., Auger, C., Minker, C., Kim, J.-H., Etienne-Selloum, N., … Schini-Kerth, V. B. (2012). Aronia melanocarpa Juice Induces a Redox-Sensitive p73-Related Caspase 3-Dependent Apoptosis in Human Leukemia Cells. PLoS ONE, 7(3), e32526.

Meinke, M. C., Lauer, A.-C., Haag, S. F., Darvin, M. E., Groth, N., & Lademann, J. (2012). Cutaneous radical scavenging effects of orally administered antioxidants measured by electron paramagnetic resonance spectroscopy. e-SPEN Journal, 7(4), e160–e166.

Parzonko, A., Oświt, A., Bazylko, A., & Naruszewicz, M. (2015). Anthocyans-rich Aronia melanocarpa extract possesses ability to protect endothelial progenitor cells against angiotensin II induced dysfunction. Phytomedicine, 22(14), 1238–1246. doi:10.1016/j.phymed.2015.10.009

Bräunlich, M., Slimestad, R., Wangensteen, H., Brede, C., Malterud, K., & Barsett, H. (2013). Extracts, Anthocyanins and Procyanidins from Aronia melanocarpa as Radical Scavengers and Enzyme Inhibitors. Nutrients, 5(3), 663–678.

Turmeric Extract

A new generation of turmeric extract with all ingredients in water-dissolvable

Turmeric whose scientific name is Curcuma longa, belongs to the ginger family turmeric. Curcumin is the primary health beneficial ingredient. Turmeric tastes spicy and bitter with warm nature. This property helps blood circulation of the body. In addition, turmeric also has anti-inflammatory effects, reduces information, improves the body micro-environment, and helps to improve chronic diseases such as obesity, arthritis, cardiovascular disease, liver damage, and far more.

The rhizome of turmeric contains a variety of Curcuminoids:

Curcumin

Demethoxycurcumin, DMC

Bisdemethoxycurcumin, BDMC

GMIPLUS® Natural Elements uses a new generation of water-dispersible turmeric extract - Curcugen™ and uses the SELFD™ patented extraction method to retain the above three natural and complete ingredients.

Combining 98.5% turmeric extract and 1.5% silica (to improve fluidity) is the only raw material that does not crystallize and purify curcumin (which is easy to lose active ingredients). It retains the complete curcuminoids and their proportions, maintaining All natural ingredients strengthen the effect of water dispersion and increase absorption.

Three characteristics of Curcugen™ raw materials

Curcugen™ -Turmeric Extract advantages

Turmeric contains biologically active compounds with powerful medicinal properties
Curcumin is a natural anti-inflammatory compound
Turmeric significantly improves the body's antioxidant capacity
Curcumin promotes brain-derived neurotrophic factors, which is related to improving brain function and reducing the risk of brain diseases
Curcumin should reduce your risk of heart disease
Turmeric helps prevent (or even treat) cancer
Curcumin may help prevent and treat Alzheimer's disease
Arthritis patients respond well to curcumin supplements
Research shows that curcumin has incredible benefits for depression
Curcumin may help delay aging and fight age-related chronic diseases

Turmeric Extract functions advantages

Antonia C., Rosa C., Chiara P., Teresa T., Rosaria S., Maria A. P., PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microglia. Int Immunopharmacol. (2016). 36:282-290.

Astragalus Extract

Astragalus is a kind of legume, mainly extracts the dried roots of Mongolian astragalus or Astragalus membranaceus as medicinal materials of traditional Chinese medicine. Astragalus is rich in polysaccharides, saponins, flavonoids, vitamins, and minerals, which can promote blood circulation, lower blood pressure, diuresis, improve renal fibrosis, lower urine protein, and immune proliferation.

The main active ingredients of Astragalus

The main effects of Astragalus

1.Cardioprotection

The flavonoids extracted from astragalus have antioxidant activity, which can inhibit LDL oxidation, reduce fatty streak on the arterial wall, reduce vascular blockage risk, promote blood circulation, and control blood pressure.

2.Kidney protection

Huangqi can prevent renal fibrosis and delay the deterioration of renal function. Huangqi inhibits the activation of renal intrinsic cells by inhibiting TGF-β, reduces the overexpression of osteopontin, reduces the infiltration and aggregation of macrophages, thereby improving renal fibrosis, and has a renal protective effect.

3.Liver protection

Astragalus polysaccharides and saponins can promote the proliferation of B cells and T cells, stimulate the activity of macrophages to improve cell phagocytosis, and have immunoproliferative effects.

Astragalus Extract Three functions advantages

Wang, Deqing; Zhuang, Yuan; Tian, Yaping; Thomas, Graham Neil; Ying, Mingzhong; Tomlinson, Brian (2012). Study of the Effects of Total Flavonoids of Astragalus on Atherosclerosis Formation and Potential Mechanisms. Oxid Med Cell Longev, 2012, 282383. doi:10.1155/2012/282383.

Haiyan Wang; Jingzi Li; Ling Yu; Yani Zhao; Wei Ding (2004). Antifibrotic effect of the Chinese herbs, Astragalus mongholicus and Angelica sinensis, in a rat model of chronic puromycin aminonucleoside nephrosis. Life Sci, 74(13), 1645-58. doi:10.1016/j.lfs.2003.08.036.

Bao-Mei Shao; Wen Xu; Hui Dai; Pengfei Tu; Zhongjun Li; Xiao-Ming Gao (2004). A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochem Biophys Res Commun, 320(4), 1103-11. doi:10.1016/j.bbrc.2004.06.065.

Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide, 4th ed. Sydney: Churchill Livingstone Elsevier, 2015.

Glutathione

Glutathione is a tripeptide composed of Glutamate, Cysteine , and Glycine. The body can synthesize by itself and coexist in each cell, especially There is a high concentration of glutathione in the liver.

The function of Glutathione

1.Antioxidant

The cysteine residue in glutathione contains a sulfhydryl group (-SH), which is a functional group involved in the redox reaction in the body, which makes glutathione possess antioxidant activity by directly neutralizing free radicals, or It is used as a cofactor of antioxidant enzymes to scavenge free radicals, reduce oxidative stress and damage, and regulate the redox homeostasis in cells. It is the highest concentration of antioxidants in cells.

At the same time, glutathione is also an important hub of the entire antioxidant system, which can promote the regeneration of antioxidants such as vitamin C and E. It can play an antioxidant multiplier effect, eliminate free radicals, and effectively terminate the chain caused by free radicals. Locking reaction, so it has the reputation of "the mother of anti-oxidation of the human body."

2.Assist the liver's detoxification function

The liver is the most important detoxification organ of the human body. The toxins or their metabolites in the body will react with the sulfhydryl groups on the glutathione in the liver to form a more hydrophilic conjugated body. Toxins are soluble in water and easily excreted from the body to play a detoxification effect.

3.Promote fat metabolism

PGC-1α is a transcriptional activation cofactor expressed in skeletal muscle, mainly involved in mitochondrial synthesis and regulation of mitochondrial function. During exercise, glutathione can promote the performance of PGC-1α in skeletal muscle, increase mitochondrial biosynthesis, increase fatty acid oxidation, and improve the decline of pH in the body, thus reducing muscle fatigue caused by exercise.

With aging, life pressure, lack of whole-grain fruits and vegetables, excessive tobacco and alcohol, excessive exercise, and excessive exposure to ultraviolet rays, toxins, and environmental pollution, the body's glutathione content will decrease rapidly, causing the body to produce a large number of free radicals and increase oxidative stress. It causes damage and increases the risk of aging, liver disease, cardiovascular disease, degenerative neurological disease, and cancer.

Glutathione

OPITAC® Glutathione is manufactured by specially selected non-based modified edible torula yeast fermented. It produces 98% high-purity natural reduced glutathione (GSH), the world's largest, most historical, highest quality, and The only glutathione obtained the US FDA-GRAS food safety certification.

Glutathione raw material advantage

Production of non-based modified edible round yeast ferment

Complete absorption and utilization characteristics

Many international scientific documents confirm that OPITAC® glutathione can be fully absorbed and utilized and significantly increase the body's glutathione content.

1.A Japanese study in the 2014 "Journal of Agricultural and Food Chemistry" pointed out:

The reduced GSH derived from the yeast can be completely transported into the body through the intestinal epithelial cells and quickly metabolized into oxidized GSSG, stored in the red blood cells and liver, and significantly increases the glutathione content body.

Kovacs-Nolan, J., Rupa, P., Matsui, T., Tanaka, M., Konishi, T., Sauchi, Y., … Mine, Y. (2014). In Vitro and ex Vivo Uptake of Glutathione (GSH) across the Intestinal Epithelium and Fate of Oral GSH after in Vivo Supplementation. J Agric Food Chem, 62(39), 9499–506. DOI：10.1021/jf503257w.

2.The Japanese study in the 2014 "Journal of Agricultural and Food Chemistry" pointed out:

After taking 50 mg glutathione per kilogram weight orally of Healthy subjects, we can observe that the white matter-bound GSH content in their blood increases significantly with in 60-120 minutes after ingestion.

Park, E. Y., Shimura, N., Konishi, T., Sauchi, Y., Wada, S., Aoi, W., … Sato, K. (2014). Increase in the Protein-Bound Form of Glutathione in Human Blood after the Oral Administration of Glutathione. J Agric Food Chem, 62(26), 6183-9. DOI：10.1021/jf501338z.

Acquired multiple International Patents and Certifications

特開平8-325144

特開平10-191963

特開平6-56884

特開平5-276895

特開2003-24011

特開2004-51534

特開2004-283125

特開2007-55962

特開2007-254324

特開2007-254325

特開2009-51768

昭64-63342

昭63-68096

昭59-151894

昭52-125687

昭62-292797

EP 0797929 A1

US 5968810

Glutathione Three functions advantages

Cristovao, F.L., Manuel, F-F., Cristina, P-W. (2006). Phenolic compounds protect HepG2 cells from oxidative damage: relevance of glutathione levels. Life Sci, 79(21), 2056-68. DOI: 10.1016/j.lfs.2006.06.042.

Honda, Y., Kessoku, T., Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., … Nakajima, A. (2017). Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study. BMC Gastroenterol, 17(1). DOI:10.1186/s12876-017-0652-3.

Michelle M. Gehringer; Enid G. Shephard; Tim G. Downing; Claudia Wiegand; Brett A. Neilan (2004). An investigation into the detoxification of microcystin-LR by the glutathione pathway in Balb/c mice. Int J Biochem Cell Biol, 36(5), 931-41. DOI: 10.1016/j.biocel.2003.10.012.

Algae Oil Powder

Algae is the bottom producer of the marine food chain. It can synthesize Omega-3 polyunsaturated fatty acids by itself, so it has the reputation of "vegetarian fish oil," It is also the most direct way to supplement Omega-3 polyunsaturated fatty acids. Compared with ordinary algae that only contain DHA, Schizochytrium sp. is rich in Omega-3 polyunsaturated fatty acids, among which DHA (Docosahexaenoic acid) and EPA (Eicasapentaenoic acid) are the most biologically active. Therefore, it is a good plant source of Omega-3 (EPA+DHA).

Studies have confirmed that: Omega-3 fatty acids (EPA+DHA) are beneficial to the brain, vision care, cognitive function improvement, cardiovascularprotection, lowering blood lipids, and immune regulation.

Docosahexaenic Acid (DHA) is the main component of cell membranes. It can enter brain cells and photoreceptor cells through the blood-brain barrier and blood-retinal barrier, respectively, to form the gray matter of the brain and the retina of the eye, and help maintain its normal nerve function. Therefore, DHA can help children's vision and brain development. For adults, it can maintain its function and slow down the deterioration of vision and memory, learning, mood, and other cognitive abilities.

Eicosapentaenoic acid (EPA) is an Omega-3 fatty acid, which can lower blood cholesterol and triglycerides, improve blood pressure, inhibit platelet aggregation and reduce thrombosis, so it is called "vascular scavenger" and can prevent cardiovascular disease.

In addition, both EPA and DHA have anti-inflammatory effects, which can inhibit the metabolism of arachidonic acid, thereby reducing the production of pro-inflammatory hormones, inhibiting inflammation, and exerting an immunomodulatory effect.

Algae Oil Powder

Algameg-3™ algae oil powder is selected from Schizochytrium sp., fermented in a closed system, deodorized and purified by multiple refining procedures, and then adopts the exclusive multi-layer micro-embedded oil seal powder technology (Multi-layer Microencapsulation PUFA-Sealing Technology) made. PUFA-Sealing™ oil-sealing powder-making technology uses multi-layer micro-embedding methods to make oil droplets into powder, and the powder can be evenly dispersed in an aqueous solution. Therefore,Algameg-3™ algae oil powder is stable and not easy to oxidize and deteriorate, has no algae smell, has a long validity period, is highly water-soluble, and has no doubts about organic solvents heavy metals, and microbial contamination. It is a high-quality plant source, Omega-3.

The main active ingredients of algae oil powder

The main effects of algae oil powder

1. Inhibit brain nerve damage

(1) Omega-3 (EPA+DHA) can inhibit the expression of pro-inflammatory cytokines in the hippocampal gyrus, promote the activation of c-Fos protein-related nerve cells, reduce nerve inflammation, and improve age-related spatial memory impairment.

(2) DHA has a protective effect on the cognitive function of Alzheimer's disease gene transgenic mice Tg2576. DHA can inhibit the cleavage of amyloid precursor protein (APP) by secretory enzymes, thereby reducing the production of β-amyloid (Aβ), and reducing the deposition of Aβ to form plaques, thus reducing the cognitive function degradation caused by brain nerve cell necrosis.

(3) DHA helps slow down the cognitive decline (ARCD) caused by aging, including visuospatial learning and episodic memory.

2. Promote cranial nerve repair

(1) Omega-3 fatty acids can improve cognitive impairment caused by traumatic brain injury (TBI). Omega-3 fatty acids can inhibit the accumulation of oxidative stress caused by TBI, avoid brain-derived neurotrophic factor (BDNF) and its downstream regulation of synaptic plasticity synapsin I (synapsin I) and cyclic adenylate monophosphate response element-binding The reduction of protein (CREB) in turn reduces the disability of nerve synapses. It achieves the purpose of protecting learning ability.

(2) Omega-3 fatty acids can be used as an antidepressant-Citalopram (Augmentation) to improve the signs and symptoms of depression effectively.

(3) EPA/DHA can prevent and relieve neuropathic pain caused by peripheral nerve injury. EPA/DHA can inhibit tumor necrosis factor (TNF) production in the spinal cord and reduce the migration of neutrophils, thereby inhibiting nerve inflammation and slowing down pain hypersensitivity. It can also stimulate remyelination and promote nerve function restoration.

algae oil powder won some international certifications

Algameg-3™ Two functions advantages

Labrousse, Virginie F.; Nadjar, Agnès; Joffre, Corinne; Costes, Laurence; Aubert, Agnès; Grégoire, Stéphane; Bretillon, Lionel; Layé, Sophie; Schunck, Wolf-Hagen (2012). Short-Term Long Chain Omega3 Diet Protects from Neuroinflammatory Processes and Memory Impairment in Aged Mice. PLoS ONE, 7(5), e36861. doi:10.1371/journal.pone.0036861.

Yurko-Mauro, K., McCarthy, D., Rom, D., Nelson, E. B., Ryan, A. S., Blackwell, A., … Stedman, M. (2010). Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement, 6(6), 456–64. doi:10.1016/j.jalz.2010.01.013.

Lim, G. P. (2005). A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model. J Neurosci, 25(12), 3032–40. doi:10.1523/jneurosci.4225-04.2005.

Wu, A., Ying, Z., & Gomez-Pinilla, F. (2004). Dietary Omega-3 Fatty Acids Normalize BDNF Levels, Reduce Oxidative Damage, and Counteract Learning Disability after Traumatic Brain Injury in Rats. J Neurotrauma, 21(10), 1457–67. doi:10.1089/neu.2004.21.1457.

Gertsik, Lev; Poland, Russell E.; Bresee, Catherine; Rapaport, Mark Hyman (2012). Omega-3 Fatty Acid Augmentation of Citalopram Treatment for Patients With Major Depressive Disorder. J Clin Psychopharmacol, 32(1), 61–4. doi:10.1097/JCP.0b013e31823f3b5f.

Silva, Rafaela V.; Oliveira, Julia T.; Santos, Bruna L. R.; Dias, Fabiana C.; Martinez, Ana M. B.; Lima, Cleverton K. F.; Miranda, Ana L. P. (2017). Long-Chain Omega-3 Fatty Acids Supplementation Accelerates Nerve Regeneration and Prevents Neuropathic Pain Behavior in Mice. Front Pharmacol, 8, 723. doi:10.3389/fphar.2017.00723.

30 Billion Probiotics

In the case of physical discomfort, chronic diseases, and even cancer, it often happens that you can't eat or have a bowel movement, causing malnutrition, unable to maintain the body's resistance and daily activities, and quickly lead to poor treatment results.

Therefore, GMIPLUS® natural elements are added with 30 billion probiotics, combined with high-quality prebiotics-berries, to reorganize the ecological balance of the intestinal flora and strengthen the intestinal nutrient absorption capacity. The balance of good bacteria and harmful bacteria helps Reduce allergic reactions, assist intestinal digestion, promote intestinal peristalsis, and prevent constipation.

Clinically, when cancer patients posted chemotherapy and radiotherapy, due to the increase of pro-inflammatory hormones, the apoptosis of intestinal epithelial cells leads to damage, bacteria are unable to colonize, diarrhea and mucositis occur, and the patients Eating conditions are prone to malnutrition problems. The clinical application of probiotics shows that probiotic strains can reduce the incidence of postoperative inflammation in cancer patients.

Four significant effects of 30 billion probiotics

30 Billion Probiotics functions advantages

Mahmoud A. M., Anne M., John S., Laila H., Plasma cobalamin and folate and their metabolic markers methylmalonic acid and total homocysteine among Egyptian children before and after nutritional supplementation with the probiotic bacteria Lactobacillus acidophilus in yoghurt matrix. Int J Food Sci Nutr. (2006);57(7-8):470-80.

Yeung, C.-Y., Chan, W.-T., Jiang, C.-B., Cheng, M.-L., Liu, C.-Y., Chang, S.-W., … Lee, H.-C. (2015). Amelioration of Chemotherapy-Induced Intestinal Mucositis by Orally Administered Probiotics in a Mouse Model. PLOS ONE, 10(9), e0138746.

IMMUNITY BALANCING

Precision Healthcare Functional supplement, Q&A

Q：How do I take MEDBRING GMIPlUS® IMMUNITY BALANCING?

It is recommended to take 2 capsules a day for daily maintenance. It is suitable before and after meals. It can be taken in separate meals and served with cold and warm water. For degenerative diseases, immune system imbalance, metabolic disorders, or aging, the recommended dosage is 4 capsules a day. In addition, for cancer patients, you can take 6 capsules daily or more, or according to the doctor's instructions.

※It is recommended to take it after consulting a professional medical physician for instructions.

Q：Who is suitable to take MEDBRING GMIPlUS® IMMUNITY BALANCING?

GMIPlUS® IMMUNITY BALANCING are suitable for people who want to balance immunity, regulate physiological functions, promote metabolism, and adjust physical fitness.

Q：Who should pay attention to using MEDBRING GMIPlUS® IMMUNITY BALANCING?

This product contains glutathione. Those who are allergic to protein should avoid taking it. In addition, pregnant women, breastfeeding women, and children over 6 years old, please consult a professional medical physician for instructions.

Q：Is it suitable to take GMIPlUS® IMMUNITY BALANCING for those who are taking the medication regularly?

The algae oil powder in this product contains Omega-3, which has an anticoagulant effect. Therefore, people with abnormal blood coagulation function may increase the anticoagulant effect. If you want to consume GMIPlUS® IMMUNITY BALANCING, please consult a professional medical physician for instructions.

Q：What are the comparative advantages of MEDBRING GMIPlUS® IMMUNITY BALANCING and products on the market?

This product integrates eleven key formulas for physical fitness adjustment, which can effectively maintain healthy body tissues and normal metabolism. It can also balance immunity, increase antioxidant effects, and balance the physiological functions of various human systems to achieve a comprehensive health protection.

Q：What are the advantages of MEDBRING GMIPlUS® IMMUNITY BALANCING compared with general commercial immunomodulatory products?

The water-dispersible turmeric extract in GMIPlUS® IMMUNITY BALANCING uses SELFD™ patented technology and 1.5% silicon dioxide combination to extract all the ingredients and proportions of turmeric completely, the content is as high as 98.5%, and it strengthens the water dispersion effect and increases bioavailability.

Glutathione is made of high-purity reduced glutathione produced by a major Japanese factory, with a content of 98%, and is made from non-based modified edible round yeast ferment. Studies have confirmed that it has anti-oxidation and liver protection effects and can be completely absorbed and utilized by the human body. It has obtained 31 international certifications and patents on safety, religion, raw materials, and quality, ensuring the safety and quality of raw materials.

Q：What is the source of MEDBRING GMIPlUS® IMMUNITY BALANCING?

The exclusive patented GMI-Immuno protein (GMI immunomodulatory protein) in GMIPlUS® IMMUNITY BALANCING is derived from the cultivation of Saccharomyces cerevisiae through precision genetic medicine. It has multiple immune regulation and anti-cancer effects and can inhibit a variety of cancer cells. Effect.

Precision medical functional supplements.

MEDBRING adheres to

the principle of professional responsibility and to uses the exclusive patented extraction from natural sources in the selection of ingredients to ensure the efficacy of the products.

Integrate the precision

only select the process with international GMP, HACCP, ISO certification laboratories of health food factories, and the production process is strictly monitored to ensure product quality.

Established

teams of a multi-national professional physician, nutritionist, pharmacist R&D laboratory to lead the development and production of high-quality functional medical supplements in the world.

Insist on the use

of ingredients that have obtained internationally relevant certifications, and the original suppliers have repeatedly tested in the laboratory or clinical to ensure that the source of ingredients is absolutely free from pollution.

Safe and secure!

The functional medical supplements series had passed a number of organic and related food certifications.

Australian
Certified Organic

Halal
Certification

Kosher Meat
Certification

ISO
9001:2000

HACCP

Quality meets the three highest international standards of FDA, EP, TGA.

(FDA Food and Drug Administration)｜(EP EU)｜ (TGA Australian Drug Administration)

Adheres to the profession. Pursuit of quality.

Rigorous attitude worthy of your trust!

Precision health supplements

Tailored health solutions

Contact us

USA：MedicLink USA Inc.
13021 Arctic Circle, Santa Fe Springs, CA 90670, USA

USA：1714-323-7135
Mail：service@medic-link.com

11 exclusive professional-grade ingredients

IMMUNITY BALANCING

Professional Ingredients Description

Professional Precision medicine formulation opens the gate to improving immunity and body functions.

GMIPLUS® Immuno Protein

GMIPLUS® Immuno Protein

8 Major product features

GMIPLUS® Immuno Protein

mainefficacy and research patents

The first brewer's yeast immunoregulatory protein

FIP-GMIPLUS® verified by transnational research

2013

The NIH experiment in the United States found that it has inhibitory effects on variety of cancer cell lines.

2016

Obtained FDA certification and passed the highest food safety standards.

US Food and Drug Administration NDI

Safety Certification.

GMIPLUS® Immuno Acquired multiple research patents

GMIPLUS® Immuno Protein THREE functions advantages

Sea Buckthorn Extract

Five Functions Of Sea Buckthorn

Contains Various Of Nutrients

Sea buckthorn is rich in fat-soluble vitamins A, D, E, K, water-soluble vitamins B1, B2, B6, B12, C, folic acid, biotin, and minerals such as potassium, calcium, magnesium, iron, and phosphorus, each of which is 100% Keyo contains 695mg of vitamin C, which is 15 times that of oranges.

Omega-7 Fatty Acid—Palmitoleic Acid

1. Support heart health

Omega-7 fatty acids can prevent thrombosis and regulate the immune system, thereby reducing inflammation and protecting heart health.

2. Reduce insulin resistance

Omega-7 fatty acids help increase insulin sensitivity and promote glucose metabolism.

3. Maintain skin health

Palmitoleic acid can increase the synthesis of elastin and collagen, making the skin youthful and moisturizing.

4. Reduce inflammation and relieve dry eye discomfort

By inhibiting inflammatory cytokines, reduce inflammation in the body,and even reduce the inflammation and pain of dry eye.

5. Balancing Cholesterol

Omega-7 fat helps increase HDL (high-density lipoprotein) cholesterol and lower LDL (low-density lipoprotein) cholesterol by balancing High-sensitivity C-reactive protein(hs-crp).

Sea Buckthorn Extract Five functions advantages

Aronia Melanocarpa Extract

Wild cherry berry is the berry with the highest anthocyanidin content, the ORAC antioxidant index of the fruit is the champion, ORAC is as high as 16,062 umol TE/100g.

ORAC

Oxygen free radical absorption capacity

Total-Oxygen free radical absorption capacity (µmol TE/100g)

The dark-colored wild cherry berries are rich in anthocyanins. Every 100 grams of fresh wild cherry berries contains up to 1480 mg of anthocyanins. Anthocyanins are bioflavonoids and have free radical scavenging and antioxidant capabilities., So it can reduce the risk of metabolic syndrome.

Total anthocyanins (mg/100g)

Aronia melanocarpa Extract Two functions advantages

Aronia berries provide antioxidants. These compounds may have cancer-fighting properties and support your heart and immune health.

Bilberry Extract

Bilberry (Vaccinium myrtillus L.) is a dark blueberry also known as the European blueberry and whortleberry. The fruit is very similar to the blueberry but can be smaller, darker, and firmer. Furthermore, bilberry has much higher levels of anthocyanins.

Anthocyanins

Protection of vascular endothelium

Improve eye fatigue

With the popularization of 3C products, people overuse their eyes, and age increases, causing free radicals in the body to rise, poor blood circulation in the capillaries around the eyes and increasing eye discomfort.

Bilberry Extract Four functions advantages

Turmeric Extract

Turmeric Extract

A new generation of turmeric extract with all ingredients in water-dissolvable

The rhizome of turmeric contains a variety of Curcuminoids:

GMIPLUS® Natural Elements uses a new generation of water-dispersible turmeric extract - Curcugen™ and uses the SELFD™ patented extraction method to retain the above three natural and complete ingredients.

Three characteristics of Curcugen™ raw materials

Curcugen™ -Turmeric Extract advantages

Turmeric Extract functions advantages

CS-4™ Cordyceps sinensis Mycelium

The active ingredients of CS-4™ Cordyceps sinensis Mycelium

The active ingredients of CS-4™ Cordyceps sinensis Mycelium

1. Lung protection

(1) Cordycepin inhibits the NF-κB signaling pathway to prevent inflammation, activates the Nrf2 signaling pathway, reduces oxidative stress, and effectively reduces LPS-induced acute lung injury.

(2) Cordycepin inhibits the proliferation, metastasis, invasion, and cell cycle of non-small cell lung cancer (NSCLC) through phosphorylation of AMPK, promotes apoptosis and prevents the progression of NSCLC.

2. Kidney protection

(1) Cordyceps CPS-2 polysaccharides can reduce ROS generation and oxidative damage through the TGF-β1 signaling pathway, effectively improve chronic renal failure, and protect kidney function.

Cordyceps sinensis Mycelium Six functions advantages

Brazilian Mushroom Extract

Active ingredients of Brazilian mushrooms

The main effects of Brazilian Mushrooms

1. Stomach protection

The linalool extracted from Brazilian mushrooms induces apoptosis of the MKN45 gastric cancer cell line with wild-type p53 through the caspase-dependent pathway and has an anti-tumor effect.

2. Intestinal health

Brazilian mushroom extract can inhibit the message transmission of LPS receptor-TLR4, reduce the production of pro-inflammatory cytokines, chemokines, and white blood cell growth factors, have anti-inflammatory effects, and help to improve inflammatory bowel diseases.

3. Liver protection

(1) Pre-oral administration of Brazilian mushroom water extract can effectively inhibit DEN-induced hepatotoxicity and the early stage of liver cancer formation and has liver protection function.

Brazilian Mushrooms Extract Six functions advantages

Astragalus Extract

The main active ingredients of Astragalus